Keywords: Neurofluids, Neurofluids, cerebrospinal fluid leak; MR myelography; intrathecal gadolinium; spontaneous intracranial hypotension; Dixon fat suppression
Motivation: Regarding fat-suppressed 3D T1-wighted sequences employed for cerebrospinal fluid (CSF) leak detection, in the literature there is a paucity of details on the fat suppression technique employed and a lack of standardisation or discussion on the optimization of the technical aspects.
Goal(s): Optimise 3D T1-wighted sequences that a) achieve complete fat suppression around the spinal canal and b) are feasible to implement on a wide range of scanners.
Approach: Develop MR myelography sequences at 1.5T considering available sequence and fat suppression options.
Results: Superior performance of Dixon fat suppression. Optimised VIBE-DIXON sequences detect leakage of contrast-opacified CSF in a clinical case.
Impact: This study supports 3D spoiled gradient echo sequences with Dixon fat suppression as a reliable option for CSF leak assessment in clinical settings.
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