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Abstract #4723

Arachnoid Granulation Characterization in Dutch-type hereditary Cerebral Amyloid Angiopathy

Balázs Örzsik1, Fleur Slot1, Manon R Schipper1, Fieke Prinse1, Thijs W van Harten1, Reinier GJ van der Zwet2, Rosemarie van Dort2, Emma A Koemans2, Sabine Voigt1, Ingeborg Rasing2, Kanishk Kaushik2, Marieke JH Wermer2,3, Jeroen de Bresser1, Marianne AA Walderveen1, and Matthias JP van Osch1
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Neurology, Leiden University Medical Center, Leiden, Netherlands, 3Neurology, University Medical Center Groningen, Groningen, Netherlands

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration, CAA, arachnoid granulations, segmentation

Motivation: Arachnoid granulations (AGs) have been largely understudied, despite their potential role in cerebrospinal fluid clearance and glymphatic-lymphatic coupling, which may be disrupted in Cerebral Amyloid Angiopathy (CAA).

Goal(s): This study aims to explore the role of AGs in Dutch-type CAA by characterizing their volume and count across different clinical stages.

Approach: AGs were segmented and analyzed in healthy controls, presymptomatic, and symptomatic D-CAA patients using high resolution MRI to assess changes in AG characteristics.

Results: AGs connected to cranial bone showed significant increases in both volume and count in symptomatic D-CAA patients, suggesting a potential role in disease-related clearance/neuroimmune disruptions.

Impact: This study highlights the role of arachnoid granulations connected to cranial bone in Dutch-type cerebral amyloid angiopathy, suggesting they may serve as biomarkers for disease progression. It opens new avenues for investigating arachnoid granulations in glymphatic-lymphatic coupling.

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