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Abstract #4741

Cerebrospinal Fluid Flow within Ventricles and Perivascular Subarachnoid Space Evaluated by Velocity Selective Spin Labeling MRI

Yihan Wu1,2, Feng Xu1,2, Dan Zhu1,2, Anna Li2, Kexin Wang1,2, Qin Qin1,2, and Jiadi Xu1,2
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: To map the recently discovered perivascular subarachnoid space (PVSAS) system and investigate cerebrospinal fluid (CSF) dynamics within it.

Goal(s): To evaluate CSF flow dynamics within the perivascular space, ventricles, and the novel PVSAS system using velocity selective spin labeling (VSSL) method.

Approach: Fourier-transform-based velocity selective inversion was employed to measure CSF flow and calibrated against phase-contrast MRI.

Results: The VSSL method successfully measured CSF flow in the PVSAS of major arteries, including middle, anterior, and posterior cerebral arteries, with average flow velocity of 0.34 ± 0.12 cm/s and weak orientation dependency. CSF flow in the ventricles (0.31 ± 0.12 cm/s) was also measured.

Impact: This study underscores the potential of VSSL MRI as a non-invasive tool for investigating CSF dynamics in both PVSAS of arteries and ventricles, offering significant insights into CSF circulation in both healthy and pathological conditions.

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