Keywords: Neurofluids, Deuterium, CSF production, b-SSFP, Indirect deuterium displacement imaging
Motivation: Non-invasive MRI techniques for CSF production evaluation remain limited by assumptions about CSF dynamics, spatial resolution constraints, and/or low signal-to-noise ratio.
Goal(s): Develop a non-invasive, high-resolution method to map CSF production accurately, addressing limitations of current invasive techniques.
Approach: Utilizing deuterium oxide as a contrast agent, MRI was performed on rat models to measure CSF production indirectly by detecting changes in signal intensity due to deuterium displacement.
Results: The method successfully visualized spatial patterns of CSF production, revealing dose-dependent, region-specific signal loss.
Impact: Deuterium displacement MRI enables precise, non-invasive mapping of cerebrospinal fluid (CSF) production, advancing neurofluid disorder research. It enhances understanding of CSF dynamics and neurotoxin clearance, especially in brain regions associated with neurodegenerative diseases.
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