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Abstract #4742

Indirect Deuterium Displacement Imaging for Non-Invasive High-Resolution CSF Production Mapping

Debolina De1, Nicholas Bateman2, Arash Nazeri2, Shelei Pan3, James D. Quirk4, and Jennifer M. Strahle3
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, United States, 2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, 3Neurosurgery, Washington University School of Medicine, St. Louis, MO, United States, 4Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States

Synopsis

Keywords: Neurofluids, Deuterium, CSF production, b-SSFP, Indirect deuterium displacement imaging

Motivation: Non-invasive MRI techniques for CSF production evaluation remain limited by assumptions about CSF dynamics, spatial resolution constraints, and/or low signal-to-noise ratio.

Goal(s): Develop a non-invasive, high-resolution method to map CSF production accurately, addressing limitations of current invasive techniques.

Approach: Utilizing deuterium oxide as a contrast agent, MRI was performed on rat models to measure CSF production indirectly by detecting changes in signal intensity due to deuterium displacement.

Results: The method successfully visualized spatial patterns of CSF production, revealing dose-dependent, region-specific signal loss.

Impact: Deuterium displacement MRI enables precise, non-invasive mapping of cerebrospinal fluid (CSF) production, advancing neurofluid disorder research. It enhances understanding of CSF dynamics and neurotoxin clearance, especially in brain regions associated with neurodegenerative diseases.

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