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Abstract #4751

Rotary Excitation based imaging of multi-frequency stimulus fields in the human brain: a method for optimization of deep brain stimulation?

Petra Albertova1,2, Luna Torres2, Martin Blaimer3, Maximilian Wessel4, Martin Reich4, Peter Michael Jakob2, Peter Nordbeck1, and Maximilian Gram1,2
1Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 2Experimental Physics 5, Julius-Maximilians University, Würzburg, Germany, 3Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany, 4Department of Diagnostic and Interventional Neuroradiology, University Hospital Würzburg, Würzburg, Germany

Synopsis

Keywords: Novel Contrast Mechanisms, Neuroscience, Spin-Lock, Rotary Excitation, Deep Brain Stimulation

Motivation: A Rotary Excitation (REX) based detection method was developed for field calibration of neurostimulation. In future, this non-invasive imaging technique could enable to localize brain regions under multi-frequency interference stimulation and thus to analyze correlation between stimulated cortical and subcortical regions and outcome.

Goal(s): Investigate whether REX imaging enables frequency-specific field detection in the presence of multi-frequency magnetic fields.

Approach: As a proof-of-concept the MRI gradient system was used to project two magnetic fields (f1=100Hz, f2=200Hz) of locally varying magnitudes onto brain tissue of a healthy subject.

Results: Detection and discrimination of the magnetic fields was possible with a spatial resolution of 2x2x5mm.

Impact: So far, non-invasive methods for patient-specific imaging of evoking fields induced by deep-brain-stimulation (DBS) do not exist. REX-based imaging could enable structured assessment of stimulation target regions via MRI and thus support the calibration and clinical testing of neurostimulation devices.

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Keywords