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Abstract #4764

VO-CEST: Variable-Optimized CEST using optimized adiabatic RF design on 3T

ZhuoCheng Xie1, Zijian Zhou1, and Peng Hu1
1Biomedical Engineering, School of Biomedical Engineering, Shanghaitech Unversity, Shanghai, China, Shanghai, China

Synopsis

Keywords: CEST / APT / NOE, CEST / APT / NOE

Motivation: To reduce the possible oscillation artifacts and improve saturation uniformity using adiabatic saturation pulse in CEST imaging.

Goal(s): This study is dedicated to improve the imaging quality and mapping accuracy when saturating under adiabatic pulse.

Approach: A variable optimization of adiabatic factor for any shape of adiabatic Spin-Lock pulse with respect to frequency offset is proposed.

Results: Oscillation artifact is fairly reduced, saturation is more uniform and mapping result is improved through better insensitivity to field inhomogeneity.

Impact: A novel protocol that focusing on optimizing the RF waveform and bandwidth is proposed and can be broadly used in tasks involving adiabatic pulses.

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