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Abstract #4772

Multi-center and multi-vendor reproducibility of PCASL data on 3T MRI scanners

Rebeca Echeverria-Chasco1, Leyre Garcia-Ruiz1, Malene Aastrup2, Veronica Aramendia-Vidaurreta1, Michela Bozzetto3, Paolo Brambilla4, Esben S.S. Hansen2, Larisa Micu5, Jose Maria Mora-Gutierrez1, Siria Pasini3, Anish Raj6, Steffen Ringgaard2, Anika Strittmatter6, Manuel Taso7, Iona Urdea5, Tau Vendelboe2, Marta Vidorreta8, Giulia Villa3, Niels Henrik Buus9, Nuria Garcia-Fernandez1, Matias Trillini3, David C. Alsop7, Susan T. Francis10, Lucian-Mihai Itu5, Christoffer Laustsen2, Frank G. Zoellner6, Anna Caroli3, and Maria A. Fernandez-Seara1
1Clinica Universidad de Navarra, Pamplona, Spain, 2The MR Research Centre, Aarhus, Denmark, 3Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, 4ASST Papa Giovanni XXIII, Bergamo, Italy, 5Siemens, Brasov, Romania, 6Medical Faculty Mannheim, Mannheim, Germany, 7Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States, 8Siemens Healthineers Spain, Madrid, Spain, 9Aarhus University Hospital, Aarhus, Denmark, 10University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Perfusion, Arterial spin labelling, Kidney, reproducibility, renal blood flow

Motivation: Facilitating reliable multi-center renal perfusion MRI studies

Goal(s): Assessing multi-center and multi-vendor reproducibility of perfusion biomarkers on 3T scanners from 2 clinical centers.

Approach: Thirty-nine healthy volunteers were scanned in two vendors in separate days. MRI protocol included a PCASL sequence harmonized between vendors. Renal blood flow (RBF) maps were generated for each subject/scan. Bland-Altman plots, ICC and CVws were assesed.

Results: Reproducibility of ASL was good for the two vendors. In addition, they showed comparable results in terms of RBF values. These findings provide evidence in favor of the need of ASL harmonization across vendors to allow reliable multi-center perfusion MRI studies.

Impact: Harmonized PCASL sequence for renal perfusion measurements shows promise for reliable multi-center and multi-vendor studies

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Abstract

Keywords