Abstract #4773

Blurring-free 3D perfusion and arterial blood T2 mapping using partition encoding reordered GRASE (PER-GRASE) ASL at 5T

Junqi Xu^1,2, Qing Wei³, Qifan Pang⁴, Weihuan Fang⁵, Xiao-Yong Zhang^4,5, Hao Li², Zhensen Chen², He Wang², Danny JJ Wang⁶, Peng Hu^7,8, Fuhua Yan^1,4,5, and Xingfeng Shao¹

¹Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, ShangHai, China, ²Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, ShangHai, China, ³Shanghai United Imaging Healthcare Co., Ltd, ShangHai, China, ⁴College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, ShangHai, China, ⁵Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁶Laboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁷Shanghai United Imaging Healthcare Advanced Technology Research Institute Co., Ltd, ShangHai, China, ⁸School of Biomedical Engineering, Shanghai Technology University, Shanghai, China

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Partition encoding reordered GRASE ASL, blurring-free

Motivation: The blurring along the slice direction using traditional 3D GRASE ASL acquisition and its reduced SNR efficiency for measuring arterial blood T2 presents notable challenges.

Goal(s): To simultaneously acquire blurring-free ASL maps and arterial blood T2 mapping at 5T.

Approach: In our method, we reordered k-space partition acquisition across TRs, achieving fully sampled k-space at each echo time after recombination. Mono/bi-exponential models were used for calculating the T2 values of blood, gray matter, and white matter.

Results: The proposed technique provides full-brain blurring-free perfusion and T2 mapping. Arterial blood increased at longer PLD, suggesting a potential peri-capillary compartment between capillary and tissue space.

Impact: We proposed a PER-GRASE ASL technique for blurring-free perfusion and arterial blood T2 mapping with full-brain coverage at 5T, which has the potential to be adapted for measuring neurovascular function such as brain oxygenation and BBB function in clinical studies.

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