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Abstract #4777

2D real-time magnetic resonance imaging to characterize myocardial oxygenation during breathing maneuvers

Ludovica Romanin1,2, Jaume Banus2, Christopher W Roy2, Jean-Baptiste Ledoux2,3, Adèle LC Mackowiak2, Ruud B van Heeswijk2, Jonas Richiardi2,3, Stanislas Rapacchi2, and Matthias Stuber2,3
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

Synopsis

Keywords: Oxygenation, Cardiovascular

Motivation: Oxygen-sensitive (OS) cardiovascular magnetic resonance (CMR) imaging with breathing maneuvers is a promising method for assessing myocardial perfusion through its oxygenation, but the lack of motion correction limits the characterization of myocardial oxygenation.

Goal(s): Continuously characterize myocardial oxygenation changes during breathing maneuvers with 2D real-time radial OS-CMR.

Approach: We implemented a 2D radial sequence with automated breath-hold detection and myocardial segmentation to track oxygen-sensitive signal during breathing maneuvers. We compared this to standard 2D Cartesian OS-CMR in healthy volunteers.

Results: Real-time continuous OS-CMR provided refined sensitivity to hyperventilation-induced signal changes and improved reproducibility compared to state-of-the-art Cartesian OS-CMR.

Impact: This study advances oxygen-sensitive CMR by introducing real-time 2D radial imaging with automated processing to continuously capture myocardial oxygenation, extending the wealth of information and the feasibility of this needle-free imaging for cardiovascular diseases.

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Keywords