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Abstract #4778

Simultaneous DCE-DSC evaluation with 3D stack-of-spiral FLASH readout

Ziming Xu1, Xiaoming Liu2, Xiaoqi Lin1, Shuwan Yu1, Haozhong Sun1, Rui Li1, and Huijun Chen1
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Synopsis

Keywords: Perfusion, DSC & DCE Perfusion, stack-of-spiral FLASH, quantitative imaging

Motivation: Dynamic contrast enhanced (DCE) and dynamic susceptibility contrast (DSC) are both essential for assessing cerebrovascular function, but their accuracy is often comprised by competing relaxation effects.

Goal(s): We aimed to develop a straightforward method enabling simultaneous DCE and DSC evaluation to improve the accuracy of assessment.

Approach: Dynamic T1 and T2* mapping was simultaneously achieved using a dual flip angle with multi-echo (DFA-ME) sequence based on efficient 3D stack-of-spiral FLASH readout.

Results: DFA-ME demonstrated strong correlation with the reference method for T1 and T2* mapping. Additionally, the permeability and perfusion parameters derived from DFA-ME were consistent with values reported in the previous literature.

Impact: DFA-ME enables whole-brain dynamic T1 and T2* mapping at 2.0×2.0×6.0 mm3 spatial resolution and a temporal resolution of 2.1 s, allowing simultaneous and accurate evaluation of DCE and DSC with a single-dose contrast injection.

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Keywords