Abstract #4780

The comprehensive Subcortical Atlas of the Human Brain (“SAHB”) derived from high-resolution multimodal MRI at 7T.

Kadharbatcha S Saleem¹, Alexandru V Avram¹, Daniel Glen², Cecil Chern-Chyi Yen³, and Peter J Basser¹

¹Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, United States, ²Scientific and Statistical Computing Core, National Institute of Mental Health (NIMH), NIH, Bethesda, MD, United States, ³Neurophysiology Imaging Facility, National Institute of Mental Health (NIMH), NIH, Bethesda, MD, United States

Synopsis

Keywords: Microstructure, Visualization, Diffusion MRI, MAP-MRI, Subcortical segmentation, white matter tracts, ex vivo human brainstem, registration, 3D atlas template

Motivation: To develop a detailed 3D atlas to help locate the subcortical subregions for anatomical, functional, and clinical studies.

Goal(s): To generate the comprehensive subcortical atlas of the human brain, using multimodal MRI ex vivo at 7T, and register it to an in vivo MNI template for 3D segmentation.

Approach: Obtained high-resolution images from the fixed brainstem at 7T using MAP-MRI with 250 μm resolution.

Results: MAP-MRI enabled detailed noninvasive segmentation of deep brain structures at a high spatial resolution.

Impact: Tracing and validating subcortical regions in 3D are imperative for neurosurgical planning for DBS, fMRI studies, cross-species comparison, and establishing brain structure-function relationships.

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