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Abstract #4835

In vivo Feasibility of an MRI-visible Interventional Device Portfolio for Neuro-oncology Applications

Bridget F Kilbride1, Pan Su2, Andrew Chu3, Dave Barry3, Teri Moore1, Kazim H Narsinh1, Daniel Cooke1, Alastair J Martin1, Mark W Wilson1, and Steven W Hetts1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Siemens Medical Solutions USA Inc., Malvern, PA, United States, 3Penumbra, Inc., Alameda, CA, United States

Synopsis

Keywords: Interventional Devices, Interventional Devices

Motivation: Traditional fluoroscopy effectively guides catheter placement in neurointerventions, but it is limited by inadequate soft tissue characterization and visualization of small intracranial vessels. MRI-guided interventions address these problems, but compatible and visible tooling hasn’t been fully realized.

Goal(s): Our goal was to evaluate the effectiveness of a passively-tracked microcatheter for intra-arterial (IA) drug delivery under real-time MRI guidance in vivo.

Approach: Susceptibility and marker patterns were evaluated during real-time MRI guidance and super-selective injection of IA gadolinium was performed.

Results: Preliminary findings in vivo demonstrated successful super-selective contrast delivery and significantly discernable tracking markers to delineate device distal tips.

Impact: Successful device integration into MRI-guided procedures enables real-time intraprocedural validation of deposition parameters and blood-brain barrier (BBB) permeability. Improved treatment efficacy could benefit patients with metastatic disease or neurodegenerative disorders requiring BBB disruption and IA therapy, among many other applications.

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Keywords