Abstract #4856

Plasma Neurofilament Light is associated with less brain tissue, larger ventricles, and higher white matter hyperintensities volume

Khalid Saifullah¹, Gulam Mahfuz Chowdhury¹, Arnold M. Evia², David A. Bennett², Julie A. Schneider², and Konstantinos Arfanakis^1,2

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Aging, biomarkers, Blood, brain, neuropathology, small vessel disease, NfL

Motivation: The relation of plasma neurofilament light (NfL), a marker of neuronal damage, with brain characteristics is not well understood.

Goal(s): Investigation the relation of NfL with brain morphometry and white matter hyperintensity (WMH) volume in non-demented older adults.

Approach: We analyzed NfL, brain morphometry, and WMH volume in 202 community-based older adults.

Results: Higher NfL levels were linked to less brain tissue, larger ventricles and higher WMH volume, suggesting NfL’s sensitivity to both neurodegenerative and vascular changes.

Impact: This study positions NfL as a non-specific marker of age-related brain pathology, supporting its use for broader assessment of brain health in clinical settings.

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