Abstract #4857

Development of Pediatric Spinal Cord Templates by Age Groups for Enhanced Quantitative MRI Analysis

Samuelle St-Onge^1,2, Nadia Blostein¹, Zahra Sadeghi Adl³, Feroze B. Mohamed³, Laura Krisa³, Devon Middleton³, Julien Cohen-Adad^1,2,4,5, and Benjamin De Leener^1,2,6

¹NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montréal, Montreal, QC, Canada, ²CHU Sainte-Justine Research Center, Montréal, QC, Canada, ³Department of Radiology, Thomas Jefferson University, Philadelphia, PA, United States, ⁴Mila - Quebec AI Institute, Montréal, QC, Canada, ⁵Functional Neuroimaging Unit, Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM), Université de Montréal, Montréal, QC, Canada, ⁶Computer Engineering and Software Engineering, Polytechnique Montréal, Montréal, QC, Canada

Synopsis

Keywords: Spinal Cord, Spinal Cord, template, pediatric, neurodevelopment

Motivation: Current pediatric spinal cord templates are lacking, limiting quantitative MRI analysis to study developmental changes in pediatric populations.

Goal(s): This study aims to create age-grouped spinal cord templates to enhance the precision of pediatric spinal cord MRI analysis.

Approach: MRI data from 115 participants were pre-processed and normalized. Template generation was performed iteratively for three age groups : 10-12, 13-15, and 16-17. Morphometric measures were extracted for age-based analysis.

Results: T1w and T2w templates were created for each age group. Morphometric analysis revealed age-related changes, supporting the need for age-specific templates to more accurately capture the developing aspects of the pediatric spinal cord.

Impact: The development of age-grouped pediatric spinal cord templates may enhance the precision of quantitative MRI analysis in the developing spinal cord, allowing to capture age-related changes and improving our understanding of spinal cord development and pathology in pediatric populations.

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