Keywords: Neurotransmission, Neurotransmission, γ-Aminobutyric Acid；Cancer-Related Depression ；Proton Magnetic Resonance Spectroscopy；MEGA-PRESS；Non-Small Cell Lung Cancer
Motivation: Cancer-related depression is prevalent with poor prognosis, yet its neurochemical mechanisms are unclear.
Goal(s): Examine GABA and Glx level changes in the mPFC of NSCLC patients.
Approach: This study included 38 NSCLC patients, categorized into depressed and non-depressed groups, along with healthy controls. MEGA-PRESS spectroscopy was employed to obtain GABA and Glx measurements.
Results: DNSCLC patients showed significantly lower mPFC GABA+/Water levels than both HC and NDNSCLC (P < 0.05), and lower Glx/Water levels than HC (P < 0.05). GABA+/Water levels correlated negatively with HAMD scores (r=-0.491) in NSCLC patients.
Impact: This study highlights specific neurochemical changes (reduced mPFC GABA+ and Glx) in depressed NSCLC patients, offering potential biomarkers for early detection of cancer-related depression.
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