Abstract #4864

Mapping structure and perfusion alterations in the hippocampus subfields and connected cortex across the adult lifespan

Jiaqi Wen^1,2, Chenyang Li¹, Zhe Sun¹, Chao Wang^1,2, Jiangyang Zhang¹, Xiaojun Xu², Thomas Wisniewski³, and Yulin Ge¹

¹Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Departments of Neurology, Pathology and Psychiatry, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Aging, Hippocampus, Subfield, Perfusion

Motivation: The structural-perfusion relationship of hippocampal subfields and connected cortex during aging remains unclear.

Goal(s): To investigate structural and vascular changes in hippocampal subfields and connected cortex during aging, and their impact on cognition.

Approach: T1-weighted and ASL data from 540 subjects in the HCP-Aging dataset were analyzed to assess volume, arterial transit time (ATT), and cerebral blood flow (CBF) of the hippocampus and connected prefrontal and entorhinal cortex.

Results: ATT in hippocampal subfields showed greater age-related vulnerability and correlation with atrophy, especially in females, with CA1 atrophy impacting cognition through delayed ATT in CA1 and the prefrontal cortex.

Impact: Using Human Connectome Project - Aging (HCP-Aging) dataset, this study revealed the relationship among structure and vascular function in the hippocampus and connected prefrontal and entorhinal cortex, mapping sex- and subfield-specific trajectories with age.

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