Meeting Banner
Abstract #4865

Taking cerebellar segmentations to the next level: 100µm resolution at 9.4T

Emma J P Brouwer1,2, Wietske van der Zwaag1,2, Nikos Priovoulos1,3, and Alard Roebroeck 4
1Spinoza Centre for Neuroimaging, Amstedam, Netherlands, 2Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, Netherlands, 3Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging FMRIB, Amsterdam, Netherlands, 4Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands

Synopsis

Keywords: Gray Matter, High-Field MRI, cerebellum

Motivation: At common spatial resolutions (±0.7-1mm), cerebellar segmentation cannot delineate smaller white matter branches. Previous work recommended ~200um voxels for cerebellar cortex delineation.

Goal(s): To test whether higher resolution imaging results in a more accurate segmentation of cerebellar grey/white matter.

Approach: A post-mortem human brain was scanned at 9.4T using a PTx multi-echo and single-echo GRE at 200/100µm. Cerebellar grey/white matter was segmented with a cerebellum-specific segmentation pipeline.

Results: In the resulting segmentations, white matter branches were longer and more continuous in the 100µm data, compared to the 200µm data. Surfaces showed finer foliations at higher spatial resolutions.

Impact: Improving spatial resolution beyond 200µm improves cerebellar segmentation and brings MRI morphometric measures closer to histology. These results imply that more detailed measures of the human cerebellum may benefit further (clinical) neuroscience studies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords