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Abstract #4868

Whole-Body and Brain Changes Associated with Alcohol Intake in Adults Without Alcohol Use Disorder

Soojin Lee1, Ahmed Gouda1, Rodrigo Solis Pompa1, Nasrin Akbari1, Saurabh Garg1, Thanh-Duc Nguyen1, Madhurima Datta1, Saqib Basar1, Yosef Chodakiewitz2, Somayeh Meysami3,4, Daniel J. Durand2, Sam Hashemi1,2, and Cyrus A. Raji5,6
1Vigilance Health Imaging Network Inc., Vancouver, BC, Canada, 2Prenuvo Inc., Vancouver, BC, Canada, 3Pacific Brain Health Center, Pacific Neuroscience Institute and Foundation, Santa Monica, CA, United States, 4Saint John’s Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA, United States, 5Washington University School of Medicine in St Louis, Mallinckrodt Institute of Radiology, St. Louis, MO, United States, 6Department of Neurology, Washington University in St. Louis, St. Louis, MO, United States

Synopsis

Keywords: Analysis/Processing, Whole Body, Alcohol

Motivation: Current research on alcohol's impact on brain structure focuses on individuals with alcohol use disorder (AUD), leaving effects on non-AUD drinkers underexplored. Moreover, no studies have simultaneously examined both brain and organ volume changes via MRI.

Goal(s): To determine if moderate to high alcohol intake is linked to structural changes in brain and whole-body metrics among non-AUD individuals.

Approach: We analyzed 1,134 MRI scans, comparing metrics in matched pairs of abstainers and drinkers, using segmentation models for body and brain volumes.

Results: Alcohol consumption group exhibited larger liver and kidney, higher visceral fat, and greater brain atrophy than abstainers, with significant cross-organ associations.

Impact: This study uniquely links alcohol consumption with structural changes in both brain and body organs among non-AUD individuals. These findings prompt further investigation into alcohol’s broader health implications, particularly concerning cross-organ relationships and their clinical significance.

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Keywords