Keywords: Analysis/Processing, Whole Body, Alcohol
Motivation: Current research on alcohol's impact on brain structure focuses on individuals with alcohol use disorder (AUD), leaving effects on non-AUD drinkers underexplored. Moreover, no studies have simultaneously examined both brain and organ volume changes via MRI.
Goal(s): To determine if moderate to high alcohol intake is linked to structural changes in brain and whole-body metrics among non-AUD individuals.
Approach: We analyzed 1,134 MRI scans, comparing metrics in matched pairs of abstainers and drinkers, using segmentation models for body and brain volumes.
Results: Alcohol consumption group exhibited larger liver and kidney, higher visceral fat, and greater brain atrophy than abstainers, with significant cross-organ associations.
Impact: This study uniquely links alcohol consumption with structural changes in both brain and body organs among non-AUD individuals. These findings prompt further investigation into alcohol’s broader health implications, particularly concerning cross-organ relationships and their clinical significance.
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