Abstract #4869

Charting cortical-layer specific area boundaries using Gibbs’ ringing attenuated T1w/T2w-FLAIR myelin MRI

Joonas A Autio¹, Akiko Uematsu¹, Takuro Ikeda¹, Takayuki Ose¹, Yujie Hou², Loïc Magrou², Ikko Kimura¹, Masahiro Ohno¹, Katsutoshi Murata³, Tim Coalson⁴, Henry Kennedy², Matthew F Glasser⁴, David C Van Essen⁴, and Takuya Hayashi¹

¹RIKEN, Kobe, Japan, ²Universite´ Lyon, Lyon, France, ³Siemens Healthcare K.K. Tokyo, Tokyo, Japan, ⁴Washington University School of Medicine, St Louis, MO, United States

Synopsis

Keywords: Gray Matter, Analysis/Processing, Myelin

Motivation: Traditionally, cortical areas are defined by their distinctive layer cyto- and/or myeloarchitecture using postmortem histology.

Goal(s): Develop MRI-based method to map myeloarchitectonic cortical layer-specific area boundaries.

Approach: We introduce a novel T1w/T2w-FLAIR method to attenuate Gibbs’ ringing artefact with image resolution matched to mean thickness of a cortical layer.

Results: Our approach delineates layer-specific cortical area boundaries, validated against Gallyas-stained myelin histology, and yields a new 182-area parcellation of the macaque cerebral cortex.

Impact: This cortical layer myelin MRI method shows strong potential for precise cortical area mapping and cross-species comparisons in a noninvasive manner.

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