Abstract #4870

Exploring brain microstructure-energy relationships with diffusion MRI and calibrated fMRI measurements

Manuela Carriero^1,2, Alessandra Caporale^1,2, Davide Di Censo^1,2, Sara Pomante^1,2, Ekaterina Bliakharskaia^1,2, Stefano Censi^1,2, Francesca Graziano^1,2, Emma Biondetti^1,2, Michael Germuska³, Valentina Tomassini^1,2, Marco Palombo^4,5, Antonio Maria Chiarelli^1,2, and Richard Wise^1,2

¹Department of Neurosciences, Imaging and Clinical Sciences, University "G. D’Annunzio", Chieti, Italy, ²Institute for Advanced Biomedical Technologies, University "G. D’Annunzio", Chieti, Italy, ³Department of Radiology, University of California Davis Medical Center, Sacramento, CA, United States, ⁴Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, School of Psychology, Cardiff, United Kingdom, ⁵School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Gray Matter, Gray Matter, Neuroenergetics

Motivation: MRI is commonly used to study brain function and microstructure separately. A joint study of brain energetics and microstructure can provide a more comprehensive characterization of brain physiology.

Goal(s): To explore relationships in grey matter (GM) of brain energy consumption and microstructure markers.

Approach: Spatial comparisons in GM were performed between CMRO₂, CBF maps (obtained from calibrated fMRI) and microstructure parameters maps, obtained from the Soma-And-Neurite-Density-Imaging (SANDI) model of DWI data.

Results: GM CMRO₂ was spatially and positively correlated with SANDI’s soma radius and density, with a stronger correlation to the former, suggesting that larger cells have higher metabolic demands.

Impact: The identified spatial coupling between oxygen consumption and soma size in GM may aid in characterizing the relationship between function and microstructure in the healthy brain.

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