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Abstract #4871

Investigating dACC glutamate modulation during inhibitory motor control: A 1H fMRS study with a novel interleaved control condition

John McClellan France1, Jillian Eichstaedt1, Dalal Khatib1, Jeffrey A. Stanley 1, and Eric Woodcock1
1Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Neurotransmission, Neurotransmission, 1H Functional Magnetic Resonance Spectroscopy

Motivation: Inhibitory control deficits are implicated in multiple psychiatric diseases yet the neural mechanisms supporting inhibitory control remain unclear.

Goal(s): Using 1H functional Magnetic Resonance Spectroscopy (1H fMRS), we measured glutamate levels in the dorsal anterior cingulate cortex (dACC) during two cognitive paradigms: one requiring only motor control (Non-Selective) and one requiring motor and inhibitory control (Selective).

Approach: We characterized shifts in dACC glutamate across Non-Selective and Selective responding using an interleaved control condition that mimicked the task conditions but without motor responses.

Results: Among healthy adults, results show elevated dACC glutamate steady state levels during motor control compared to an interleaved control condition.

Impact: The current study advances the application of 1H fMRS by identifying differential glutamate modulation under cognitive control processes known to be impaired in psychiatric disorders.

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