Abstract #4872

NOE Imaging of Multiple Sclerosis Subjects at 7T Detects Diffuse Contrast Changes

Paul S. Jacobs¹, Anshuman Swain¹, Neil E. Wilson¹, Fang Liu², Blake Benyard¹, Bailey Spangler², Madeleine Seitz², Allen Fu², Ravi Prakash Reddy Nanga¹, Mark Elliott¹, Amit Bar-Or³, John Detre³, Jennifer L. Orthman-Murphy³, Matthew Schindler³, and Ravinder Reddy¹

¹Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Penn Statistics in Imaging and Visualization Endeavour, Department of Biostatistics, Epidemiology, & Informatics, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Multiple Sclerosis, CEST / APT / NOE, 7T, Multiple Sclerosis, white matter, gray matter

Motivation: While standard to the diagnosis of multiple sclerosis (MS), conventional structural MRI cannot provide detailed information on changes in lipid metabolism.

Goal(s): To utilize NOE imaging to investigate changes between MS and healthy control subjects.

Approach: NOE imaging was performed on 15 MS and 10 healthy subjects in conjunction with a multi-pool Lorentzian line fitting model to produce several contrasts including MT, APT, amine, and rNOE.

Results: Statistically significant contrast decreases were observed in both the amine (15.3% in NAWM) and rNOE (11.4% in NAWM and 10.6% in NAGM) pools.

Impact: This 7T NOE imaging method for patients with MS can provide complementary lipid metabolic information to standard structural imaging and can yield improved diagnostic outcomes for this patient population.

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