Abstract #4879

Potential association between cognitive impairment and pre-pregnancy Body mass index in women with preeclampsia

Yuanyuan Wang^1,2, Xinyue Zhang³, Na Wang⁴, Linfeng Yang⁵, Tao chen⁶, and Lingfei Guo²

¹School of Medical Imaging, Binzhou medical university, Yantai, China, ²Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ³Shandong Provincial Hospital affiliated Shandong First Medical University, Jinan, China, ⁴Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁵Department of Radiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁶Department of Clinical laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, jinan, China

Synopsis

Keywords: Gray Matter, Brain

Motivation: There is no study on magnetic resonance structural imaging combined with cognitive related proteins to evaluate brain damage in preeclampsia patients

Goal(s): The objective of this study was to explore the specific neuroimaging manifestations of PE patients and their potential correlation with cognitive impairment.

Approach: Voxel-based morphometry (VBM) was used to analyze the differences in gray matter volume (GMV) among the three groups.

Results: The specific brain structural changes in PE patients were reduced GMV in the right middle temporal gyrus and superior temporal gyrus.

Impact: Our findings suggest that the reduction of GMV volume in bilateral frontal and temporal lobes in PE patients can be used as a potential neuroimaging indicator of brain injury.

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