Meeting Banner
Abstract #4882

Brain Structural and Functional Connectivity Alterations in Heart Failure Patients

Cunxue Pan1, Yutao Pan1, Wenyi Tang2, Qing Xie1, Taoyu Jia1, Yuqing Qiu1, Ling Lu1, and Jian Chen2
1Radiology Department, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China, 2Department of Cardiovascular Medicine, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China

Synopsis

Keywords: Gray Matter, Gray Matter, brain, heart failure, neuro, fMRI, Functional Connectivity, Nervous system

Motivation: To understand the specific brain structural alterations and functional connectivity changes in heart failure (HF) patients, influenced by HF etiology, which contribute to cognitive deficits.

Goal(s): This study aims to delineate brain changes in HF patients compared to controls, focusing on the impact of HF etiology on neurological manifestations.

Approach: A prospective study of 35 HF patients and 12 controls underwent cardiovascular exams, cognitive assessments, and brain MRI scans, utilizing VBM and functional connectivity analysis.

Results: HF patients showed atrophy in brain regions linked to memory and executive functions, enhanced functional connectivity, and reduced cortical thickness, indicating structural and functional brain alterations.

Impact: This study provides insights into the neurological consequences of heart failure, potentially guiding the development of interventions for associated cognitive decline.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords