Abstract #4893

Ultra-low Field Portable MRI as a Neuroimaging Tool to Identify and Characterize Brain Atrophy in Patients with Neurodegenerative Diseases

Ajay Pathakamuri¹, Habeeb Faraaz Kazimuddin¹, Justin Kwan², Lisa Christine Turtzo³, Lawrence Latour³, and Silvina Horovitz¹

¹Mobile Clinical Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, ²Neurodegeneration Disorders Clinic, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, ³The Acute Cerebrovascular Diagnostics Unit,, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Synopsis

Keywords: Other Neurodegeneration, Low-Field MRI, Neurodegenerative disorders, portable MRI, atrophy, super resolution

Motivation: Neuroimaging is an important tool in diagnosing and characterizing neurodegenerative disorders, yet it is not readily accessible.

Goal(s): We aimed to determine if a lower-cost ultra-low field (ULF) portable MRI machine could identify brain atrophy with a similar sensitivity as standard MRI.

Approach: We segmented paired 3T and ULF (64mT) MRI brain images from patients with neurodegenerative disorders and healthy controls and performed a clustering analysis based on morphometric features indicative of brain atrophy.

Results: We found that ULF can identify brain atrophy with similar specificity and sensitivity to 3T (ULF Sensitivity: 82% and Specificity: 92%; 3T Sensitivity: 83% and Specificity: 87%).

Impact: Ultra-low field (ULF), portable MRI can identify brain atrophy with a similar sensitivity and specificity as standard 3T MRI. ULF may serve as a more accessible clinical research and diagnostic tool to identify and understand neurodegenerative disease mechanisms.

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