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Abstract #4899

Altered Functional Connectivity and Metabolism of the Anterior Cingulate Cortex in Parkinson’s Disease

Wei Su1, Qichao Cheng2, Jiaxiang Xin3, Yingli Gao1, Qianwen Zhang1, Xuan Li1, Shijia Zhao1, Feng Xue2, and Kaihua Zhang1
1School of Psychology, Shandong Normal University, Jinan, China, 2Department of Radiology, Qilu Hospital of Shandong University, Qilu Medical Imaging Institute of Shandong University, Jinan, China, 3MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state)

Motivation: Resting-state functional magnetic resonance imaging (rs-fMRI) and ¹H magnetic resonance spectroscopy (MRS) offer complementary insights into brain function and metabolism.

Goal(s): To investigate the relationship between changes in brain function and metabolism in patients with Parkinson’s disease (PD) using rs-fMRI and MRS techniques.

Approach: The anterior cingulate cortex (ACC) was selected as the region of interest, and correlations between alterations in brain function and metabolic markers, such as γ-aminobutyric acid and macromolecules (GABA+), were evaluated.

Results: A significant negative correlation was observed between ALFF values and GABA+ levels in the ACC.

Impact: Integrating rs-fMRI and MRS in PD research could uncover the bidirectional relationship between functional connectivity and metabolism, enhancing our understanding of future brain dynamics changes.

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Keywords