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Abstract #4903

Glymphatic System Impairment in Different Stages of Parkinson's Disease: Evidence from DTI-ALPS Imaging

Cheng Lai1,2, Suyi Zhou3, Zhiming Zhen3, Zhentao Zuo1,2, and Wei Chen3
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Department of Radiology, Southwest Hospital, Chongqing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, glymphatic dysfunction, DTI-ALPS

Motivation: Understanding the role of brain glymphatic dysfunction in Parkinson's disease (PD) is crucial for exploring potential therapeutic targets.

Goal(s): To evaluate the abnormality of ALPS-index and its association with clinical parameters in PD patients.

Approach: 71 PD patients and 102 healthy controls underwent MRI scans. The ALPS index was calculated using DTI-ALPS. PD patients were classified into early and advanced stages using k-means. Statistical analyses compared groups and correlations.

Results: 44 early PD and 27 advanced PD patients. Advanced PD showed significantly lower ALPS-index compared to HCs and early PD, with better diagnostic performance (AUC=0.71) and significant correlations with age and disease severity.

Impact: Alps-index changes intensify in advanced PD stages, indicating potential as a progression marker. This emphasizes the need for longitudinal studies to validate it as a tool for monitoring PD progression and assessing therapeutic interventions.

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