Keywords: Parkinson's Disease, Parkinson's Disease, DTI
Motivation: To explore the potential factors of cognitive decline in patients with Parkinson's disease (PD).
Goal(s): Whether glymphatic makers mediate the relationship between sleep distorder/neuroinflammation and cognitive performance in PD patients.
Approach: Statistical methods used partial correlation analysis and mediation analysis.
Results: Glymphatic markers as a significant mediator between sleep disorder/ neuroinflammation between cognitive performanceon on PD participants.
Impact: Our study provided evidence that both sleep disorder and neuroinflammation were associated with glymphatic dysfunction, which is further related to cognitive impairment. These results may provide a theoretical basis for new targets for treating PD.
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