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Abstract #4910

Sex-Specific Brain Morphological and Network Differences in Parkinson's Disease Parkinson’s with Rapid Eye Movement Sleep Behavior Disorder

Yang Liu1, Liang Zhou1, and Jing Zhang1
1The Second Hospital of Lanzhou University, lanzhou, China

Synopsis

Keywords: Parkinson's Disease, Neurodegeneration

Motivation: It remains unclear whether there exists a sex-specific pattern of altered brain morphology in Parkinson’s disease (PD) patients with rapid eye movement sleep behavior disorder

Goal(s): Investigate sex differences in male and female patients with PD-RBD in terms of cortical morphology and individual structural covariant networks.

Approach: gray matter volume (GMV) and cortical morphology metrics were obtained, Idividual-level morphological similarity networks were constructed.

Results: In the PD-pRBD group, males showed lower GMV in frontal and temporal lobes than females, while females had lower gyrification index (GI) in these regions. Graph-based analysis indicated lower network integration in males, especially in fractal dimension (FD) networks.

Impact: By examining the distinct stages of disease progression in PD patients alongside sex-specific differences, this research aims to identify resultant variations as potential targets for non-pharmacological interventions, such as transcranial magnetic stimulation (TMS), to support individualized treatment strategies.

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