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Abstract #4917

Investigating Hepatic Lipid Oxidation Using Deuterium MRI in an animal model Subjected to Gubra-Amylin NASH (GAN) Diet

Gaurav Sharma1, Vinay Malut1, Geraldine Pierre1, Mario C. Chang1, Anna Rushin1, Dalton Graham1, Arshee Badar1, Manoj Madheswaran1, Marc McLeod2, Anthony Giacalone1, and Matthew E. Merritt1
1Biochemistry and Molecular Biology, UNIVERSITY OF FLORIDA, GAINESVILLE, FL, United States, 2UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Biology, Models, Methods, Metabolism

Motivation: Early, non-invasive detection of liver disease progression to MASH is challenging yet crucial. Traditional imaging often misses subtle metabolic changes essential for early diagnosis.

Goal(s): This study assesses hepatic β-oxidation and oxidative efficiency in a mouse model of MASLD, leveraging the clinically relevant GAN diet, which closely simulates human MASH pathology.

Approach: We developed a method for estimating hepatic β-oxidation from the metabolism of [2H15]octanoate to deuterated water and detection with deuterium magnetic resonance methods.

Results: GAN diet-fed mice showed increased HDO production, reflecting elevated β-oxidation and impaired oxidative efficiency, particularly in the fed state and later stages.

Impact: This study demonstrates the utility of DMRI for non-invasive detection of diet-induced hepatic metabolic dysfunction, advancing early diagnostics for metabolic liver diseases.

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