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Abstract #4921

MRS measurement of Chronic intermittent ethanol exposure effects on Metabolites alterations during withdrawal in mouse brain.

Asamoah Bosomtwi1,2, Roxan Ara1, Hyunjung Kim3, Aubrey Bennett3, David Thomas3, and Seungwoo Kang3
1Georgia Cancer Center, Augusta University, Augusta, GA, United States, 2Biochemistry and Molecular Biology, Augusta University, Augusta, GA, United States, 3Pharmacology & Toxicology, Augusta University, Augusta, GA, United States

Synopsis

Keywords: Preclinical Image Analysis, Animals

Motivation: Many brain chemicals are of critical importance in alcohol-related neuropathology and in fact are targeted by different measurement methodologies: molecular imaging methods such as PET and SPECT to study various receptors present in the brain. To create a measurable signal, however, it is necessary to inject specifically synthesized short-lived radioactive tracers into the blood stream

Goal(s): Magnetic resonance spectroscopy (MRS) on the other hand does not require the use of an exogenous agent to yield a signal from chemicals in the brain.

Approach: In vivo 1H MRS performed in a selected ROI

Results: Myo-Ins depletion could be astrocytes response against cell swelling.

Impact: In vivo 1H magnetic resonance spectroscopy techniques were applied to reveal biochemical changes in the mouse brain caused by prolonged ethanol consumption.

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