Meeting Banner
Abstract #4927

Ingesting methylcellulose fibre gels are as effective as psyllium in reducing colonic fermentation of inulin – a first step to IBS symptom relief

Neele Dellschaft1,2, Alaa Alhasani2,3, Joshua Reid4, Abi Spicer1,2, Caroline Hoad1,2, Luca Marciani2,3, Penny Gowland1,2, and Robin Spiller2,3
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, 3Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, 4Division of Food, Nutrition and Dietetics, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Digestive, Body, Digestive; Diet; IBS; colon; fermentation; functional food

Motivation: People with IBS often restrict their intake of FODMAPs (poorly absorbed fermentable carbohydrates) that produce gas and abdominal discomfort. This diet is low in fibre, which increases the risk of diabetes and colon cancer.

Goal(s): To determine whether adding a low-cost fibre methylcellulose, widely used in food manufacturing, will moderate colonic fermentation of FODMAP inulin to an extent similar to the more expensive psyllium.

Approach: 3-way randomised crossover study giving inulin with methylcellulose, psyllium or placebo in 22 healthy volunteers.

Results: We show that methylcellulose in gel form is equally good as psyllium at reducing colonic gas after inulin

Impact: Methylcellulose reduces colonic gas produced by dietary FODMAPs in healthy volunteers. If replicated in patients with IBS-C, then methylcellulose could form a low-cost dietary additive to enable people with IBS-C to eat a health-promoting diet with less abdominal pain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords