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Abstract #4930

Functional and structural connectivity changes in a 6-OHDA Parkinsonian model

Shuyi Zhu1,2, Maurizio Bergamino1, Alberto Fuentes1, Ivette M. Sandoval1, David J. Marmion1, Christopher Bishop3, Fredric P. Manfredsson1, and Ashley M. Stokes1
1Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, tempe, AZ, United States, 3Department of Psychology, Binghamton University, Binghamton, NY, United States

Synopsis

Keywords: Preclinical Image Analysis, preclinical image analysis

Motivation: Parkinson’s disease(PD) is marked by degeneration of dopaminergic neurons, yet the structural and functional connectivity changes underlying this pathology remain unclear.

Goal(s): Our study aims to identify connectivity alterations related to PD deficits and adaptations, with FW-DTI for structural specificity.

Approach: This study employs a combined FC and SC analysis with FW-DTI for structural specificity in 6-OHDA PD rat model that recapitulates dopaminergic degeneration.

Results: Functional changes showed increased connectivity in motor-related networks and decreased connectivity in sensory-cognitive regions. Structurally, sensory pathways exhibited reduced connectivity aligned with PD-related deficits. FW-DTI analysis within SC-identified abnormal tracts highlighted microstructural changes linked to PD pathology.

Impact: These findings underscore the value of integrating FC and SC analysis with FW-DTI in the 6-OHDA model, offering insights into PD pathology and potential biomarkers for neurodegenerative progression.

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Keywords