Keywords: Preclinical Image Analysis, preclinical image analysis
Motivation: Parkinson’s disease(PD) is marked by degeneration of dopaminergic neurons, yet the structural and functional connectivity changes underlying this pathology remain unclear.
Goal(s): Our study aims to identify connectivity alterations related to PD deficits and adaptations, with FW-DTI for structural specificity.
Approach: This study employs a combined FC and SC analysis with FW-DTI for structural specificity in 6-OHDA PD rat model that recapitulates dopaminergic degeneration.
Results: Functional changes showed increased connectivity in motor-related networks and decreased connectivity in sensory-cognitive regions. Structurally, sensory pathways exhibited reduced connectivity aligned with PD-related deficits. FW-DTI analysis within SC-identified abnormal tracts highlighted microstructural changes linked to PD pathology.
Impact: These findings underscore the value of integrating FC and SC analysis with FW-DTI in the 6-OHDA model, offering insights into PD pathology and potential biomarkers for neurodegenerative progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords