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Abstract #4931

CEST and DT-MRI detected early brain changes due to nicotine use in mice

Anushka Sajja1, Jayasindu Mathiyazhagan2, Micah Summerlin1, Aditya N. Bade1, and Yutong Liu2
1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States, 2Department of Radiology, University of Nebraska Medical Center, Omaha, NE, United States

Synopsis

Keywords: Biomarkers, Brain, Nicotine, Drug abuse, substance use disorder, DTI, CEST, MRI, Imaging

Motivation: In vivo detection of structural and metabolite alterations in the brain due to nicotine can provide insights into understanding brain damage and therapeutic efficacy.

Goal(s): To investigate in vivo image-based biomarkers to measure brain alterations caused by nicotine.

Approach: CEST and DT-MRI were performed in mice at baseline and after nicotine administration for 12 days. The qualitative MRI measures were computed and compared in multiple brain regions.

Results: Fractional Anisotropy showed significant changes in multiple brain regions between pre- and post-nicotine administration. Increased glutamate and NOE exchange saturation transfer rates were observed in gray matter regions.

Impact: The outcome of this study would provide in vivo image-based biomarkers to monitor brain alterations and improve our understanding of the effect of nicotine in various brain regions and therapeutic responses.

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