Keywords: Biomarkers, Brain, Nicotine, Drug abuse, substance use disorder, DTI, CEST, MRI, Imaging
Motivation: In vivo detection of structural and metabolite alterations in the brain due to nicotine can provide insights into understanding brain damage and therapeutic efficacy.
Goal(s): To investigate in vivo image-based biomarkers to measure brain alterations caused by nicotine.
Approach: CEST and DT-MRI were performed in mice at baseline and after nicotine administration for 12 days. The qualitative MRI measures were computed and compared in multiple brain regions.
Results: Fractional Anisotropy showed significant changes in multiple brain regions between pre- and post-nicotine administration. Increased glutamate and NOE exchange saturation transfer rates were observed in gray matter regions.
Impact: The outcome of this study would provide in vivo image-based biomarkers to monitor brain alterations and improve our understanding of the effect of nicotine in various brain regions and therapeutic responses.
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