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Abstract #4932

Evaluating Age-Related Brain Changes in the Female Ferret

Laurel Dieckhaus1, Leili Falbinan1, Jesus Mendoza2, Alvaro Cruz1, Rhea Carlson1, Eva Orozco3, and Elizabeth Hutchinson1
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Neuroscience, University of Arizona, Tucson, AZ, United States, 3University of Maryland, College Park, MD, United States

Synopsis

Keywords: Biomarkers, Aging, Ferret, Morphology

Motivation: An open-ended question in normal aging is how the brain changes over time and which regions are most susceptible to age-related changes.

Goal(s): Using bias-free voxel-wise approach and evaluating warp fields using the logarithm of the determinant of the Jacobian (LogJ), we investigated age-related changes in the female ferret.

Approach: We imaged four female ferrets at 1-2 years of age and later at 3-4 years of age using diffusion tensor imaging.

Results: Average LogJ maps revealed 24.8% reduction in the superior colliculus.

Impact: Voxel-wise morphology in the ferret allows us to track age-related changes in a longitudinal fashion.

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Keywords