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Abstract #4933

Molecular MR Imaging of Neuroinflammation in Sepsis-Associated Encephalopathy: An Animal Study Using Amide Proton Transfer CEST

Do-Wan Lee1, HyunJu Ryu2, Chul-Woong Woo3, Hwon Heo3, Dong-Cheol Woo3,4, and Donghoon Lee5
1University of Ulsan College of Medicine, Seoul, Korea, Republic of, 2Faculty of Health Sciences, Higher College of Technology, Dubai, United Arab Emirates, 3Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, 4University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, Republic of, 5Faculty of Health Sciences, Higher Colleges of Technology, Seoul, Korea, Republic of

Synopsis

Keywords: Small Animals, biomarkers

Motivation: The need for improved early detection of sepsis-associated encephalopathy (SAE) drives this study, addressing the limitations of current diagnostic imaging techniques.

Goal(s): To evaluate if APTw imaging, supported by mpMRI, can detect early neuroinflammatory changes in a sepsis rat model, serving as a potential biomarker for SAE.

Approach: A controlled rat model was used, with groups receiving varying LPS doses. APTw imaging and mpMRI were performed 24 hours post-injection to assess signal changes.

Results: SEPS05 and SEPS10 groups showed significantly increased APTw and T1 signals, indicating successful identification of early inflammation markers in SAE.

Impact: This study highlights APTw imaging's potential to transform early SAE diagnosis, aiding clinicians in timely intervention. It prompts further research on molecular imaging biomarkers for inflammation and opens new avenues for developing targeted therapies for sepsis-induced brain injury.

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