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Abstract #4937

Associations of MRI-Derived Glymphatic System Impairment with White Matter Microstructure Damage in Trigeminal Neuralgia

Jingqi Jiang1, Jun wang1, pengfei zhang2, kai ai3, fei jia1, zhuo wang1, wenjing huang1, and jing zhang1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, lanzhou, China, 2Department of Radiology, West China Hospital of Sichuan University, chengdu, China, 3Department of Clinical and Technical Support, Philips Healthcare, Xi’an, China

Synopsis

Keywords: Peripheral Nerves, Peripheral Nerves

Motivation: The alterations of brain metabolism and white matter microstructure in TN patients are not conclusive.

Goal(s): This study aims to quantify alterations in cerebral glymphatic function and white matter microstructure in patients with TN, and to examine the relationship between these changes and their impact on clinical symptoms.

Approach: The DTI-ALPS index was employed to evaluate the brain's capacity for clearing metabolic waste, while the TBSS method was utilized to analyze diffusion data.

Results: The changes in white matter microstructure mediate the effects of the reduced DTI-ALPS index on pain severity and psychological well-being scores in TN patients.

Impact: This research represents a pioneering investigation of cerebral glymphatic function and white matter microstructure in TN patients utilizing both DTI-ALPS index and NODDI, as well as examining their associations with pain severity and psychological well-being scores.

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Keywords