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Abstract #4942

In-vivo 7T 1H-MRS reveals different time courses of brain acetone and β-hydroxybutyrate after oral ketone monoester administration

Seyma Alcicek1,2,3,4, Danielle A. Bazer5,6, Lindsay Blair5,6, İpek Özdemir1, Zahra Shams1,7, Jannie Wijnen7, Vivek Yedavalli1, Matthias Holdhoff5,6, John Laterra5,6, Karisa C. Schreck5,6, David O. Kamson5,6, and Georg Oeltzschner1
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany, 3University Cancer Center Frankfurt (UCT), Frankfurt am Main, Germany, 4German Cancer Research Center (DKFZ) Heidelberg, Germany and German Cancer Consortium (DKTK), Partner Site Frankfurt/Main, Frankfurt am Main, Germany, 5Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 7Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Pharmacology, Metabolism, β-hydroxybutyrate, ketone bodies, glioma, IDH mutation, nutritional interventions, ketosis

Motivation: Exogeneous ketone body supplementation may achieve some of the health benefits of ketosis without imposing a restrictive diet and fasting.

Goal(s): To investigate the pharmacokinetics of ketone bodies in the brain after ketone monoester (KME) supplementation using high-field 1H-MRS in healthy controls and patients with IDH-mutant glioma.

Approach: Participants were measured using 7T 1H-MRS following KME ingestion to non-invasively detect and quantify ketones and cerebral metabolites over time.

Results: Ketone signals, i.e., β-hydroxybutyrate and acetone, are clearly resolved in MR spectra. β-hydroxybutyrate level increased immediately after KME-ingestion, peaking around one hour, whereas acetone levels exhibited a more gradual rise.

Impact: Ketone monoester supplementation is a complementary therapeutic strategy for many diseases, but data on ketone dynamics in the brain are limited. High-field MRS can be used to investigate pharmacokinetics of ketones in healthy tissue as well as in tumors.

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Abstract

Keywords