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Abstract #4943

Diffusion MRI as A Biomarker for Monitoring Recovery After Surgical Repair of Traumatic Peripheral Nerve Injuries: A Case-Series Study

Isaac Manzanera Esteve1, Sara Chaker1, Ricardo Torres-Guzman1, Yao Jun1, Barite Gutama1, Ronald Cornely1, Ping Wang2, Sharon Christopher2, Galen Perdikis1, Richard Dortch2, and Wesley Thayer1
1Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

Keywords: Peripheral Nerves, Diagnosis/Prediction

Motivation: Currently, there are no reliable, non-invasive biomarkers capable to early identify repair of severe peripheral nerve injuries cases that require additional surgical intervention.

Goal(s): FA monitor clinical axonal regeneration after surgical repair of traumatic peripheral nerve injuries.

Approach: A novel mathematical model to identify and characterize multiple sections based on slice-wise FA values of the Ulnar and Median nerves following nerve repair provided an automated and consistent approach.

Results: Results accurately matched clinical assessments of traumatic peripheral nerve injury recovery. These results supports FA as a biomarker of nerve recovery after nerve repair surgery and aid clinical decisions for timely interventions.

Impact: This study provides insight into the evolution of FA values along the nerve during recovery, providing for an automated and consistent approach to identify cases that require surgical inventions.

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