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Abstract #4944

Intrinsic Functional Connectivity as a Moderator and Consequence of Cocaine Self-Administration in Rats

LiMing Hsu1, Domenic Cerri1, Sung-Ho Lee2, Tatiana Shnitko2, Regina Carelli3, and Yen-Yu Ian Shih2
1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Department of Neurology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Dept. of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Pharmacology, fMRI (resting state), small animals

Motivation: This study investigates the effects of cocaine self-administration on functional connectivity between brain regions in rats, specifically focusing on the anterior insular and retrosplenial cortex.

Goal(s): To understand how functional connectivity changes between these regions as a consequence of cocaine exposure.

Approach: Using fMRI, significant changes in connectivity were observed over time, linked to escalated cocaine intake and prolonged abstinence.

Results: The findings suggest that functional connectivity between the anterior insular and retrosplenial cortex not only changes as a consequence of cocaine exposure but also serves as a moderator of addiction-related behaviors, highlighting potential targets for intervention in cocaine use disorders..

Impact: This study provides new insights into how brain network connectivity is both altered by and predictive of cocaine use, suggesting new circuit-based treatment strategies.

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