Keywords: Pharmacology, fMRI (resting state), small animals
Motivation: This study investigates the effects of cocaine self-administration on functional connectivity between brain regions in rats, specifically focusing on the anterior insular and retrosplenial cortex.
Goal(s): To understand how functional connectivity changes between these regions as a consequence of cocaine exposure.
Approach: Using fMRI, significant changes in connectivity were observed over time, linked to escalated cocaine intake and prolonged abstinence.
Results: The findings suggest that functional connectivity between the anterior insular and retrosplenial cortex not only changes as a consequence of cocaine exposure but also serves as a moderator of addiction-related behaviors, highlighting potential targets for intervention in cocaine use disorders..
Impact: This study provides new insights into how brain network connectivity is both altered by and predictive of cocaine use, suggesting new circuit-based treatment strategies.
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