Keywords: Functional/Dynamic, High-Field MRI, Nonalcoholic fatty liver disease, proton density fat fraction, 5.0 T
Motivation: Since early NAFLD is reversible, early detection and intervention, progression to irreversible liver damage, and other long-term NAFLD complications should be indicated.
Goal(s): Before MRI-based PDFF is performed at 5.0 T, the agreement between the PDFF measurements in the liver, pancreas, kidney, and paraspinal muscle should be determined at 3.0 T and 5.0 T.
Approach: MRI-based PDFF were obtained from the liver, pancreas, kidney, and paraspinal muscle in 120 healthy and NAFLD subjects on 3.0 T MRI 1, 3.0 T MRI 2, 5.0 T MRI.
Results: PDFF showed high reproducibility for all organs within the same field and across-field strength in NAFLD subjects.
Impact: 5.0 T is a reliable noninvasive biomarker of PDFF measurements in abdominal organs and may be helpful for early screening of NAFLD diseases.
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