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Abstract #4954

Reproducibility of MRI-based PDFF Quantification of Liver, Pancreas, Kidney, and Paraspinal Muscle on MRI at 5 T and 3 T in NAFLD subjects

Yali Li1 and Huishu Yuan1
1Department of Radiology, Peking University Third Hospital, Beijing, China

Synopsis

Keywords: Functional/Dynamic, High-Field MRI, Nonalcoholic fatty liver disease, proton density fat fraction, 5.0 T

Motivation: Since early NAFLD is reversible, early detection and intervention, progression to irreversible liver damage, and other long-term NAFLD complications should be indicated.

Goal(s): Before MRI-based PDFF is performed at 5.0 T, the agreement between the PDFF measurements in the liver, pancreas, kidney, and paraspinal muscle should be determined at 3.0 T and 5.0 T.

Approach: MRI-based PDFF were obtained from the liver, pancreas, kidney, and paraspinal muscle in 120 healthy and NAFLD subjects on 3.0 T MRI 1, 3.0 T MRI 2, 5.0 T MRI.

Results: PDFF showed high reproducibility for all organs within the same field and across-field strength in NAFLD subjects.

Impact: 5.0 T is a reliable noninvasive biomarker of PDFF measurements in abdominal organs and may be helpful for early screening of NAFLD diseases.

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