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Abstract #4955

Diffusion Tensor Imaging Visualizes the Orientations of Muscle Bundles in Isolated Smooth Muscle Layers of the Colon

MASAYUKI YAMAGUCHI1, Koji Ikeda2, Sachiko Isono3, Yutaka Machii3, Mizuki Akatsuka1, Yuichi Yamashita3, Yoshihisa Muramatsu1, Hitoshi Kanazawa3, Masaaki Ito2, Hiroshi Kusahara3, and Tatsushi Kobayashi1
1Department of Diagnositc Radiology, National Cancer Center Hospital East, Kashiwa, Japan, 2Department of Colorectal Surgery, National Cancer Center Hospital East, Kashiwa, Japan, 3MRI System Division, Canon Medical Systems Corporation, Otawara, Japan

Synopsis

Keywords: Digestive, Tissue Characterization

Motivation: Diffusion-tensor imaging (DTI) of isolated smooth muscle layers may provide deep insight into microstructure of muscular bundles in the digestive tract.

Goal(s): To demonstrate the feasibility of DTI for isolated smooth muscle layers.

Approach: We isolated smooth muscle layers from the porcine colon by immersing them into a nitric acid solution and performed DTI of those specimens using a combination of a 3T-whole body scanner and small solenoidal coil.

Results: DTI clearly visualized the orientation of 3–4 mm-thick muscle bundles being perpendicular to each other. It is suggested that DTI of isolated smooth muscle layers is technically feasible.

Impact: Our study results suggest a different approach from the conventional image-histology correlation to investigate smooth muscle layers in the digestive tract that might provide microenvironment closely relevant to cancer invasion in the gastro-intestinal organs.

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Keywords