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Abstract #4956

Quantification of the Proton Density Fat Fraction and Iron Content: A Comparative Study Between 3.0 T and 5.0 T MRI

Yali Li1 and Huishu Yuan1
1Department of Radiology, Peking University Third Hospital, Beijing, China

Synopsis

Keywords: Other Musculoskeletal, High-Field MRI, Proton density fat fraction; R2* quantification

Motivation: With the increasing availability of 5.0 T scanners, the feasibility of fat content and iron burden needs to be reevaluated at 5.0 T.

Goal(s): To determine the accuracy and consistency of the PDFF and R2* in the liver, pancreas, kidney, and paraspinal muscle across different magnetic strengths and MR scanners.

Approach: 127 participants underwent 3.0 T MRI 1 (uMR 780), 3.0 T MRI 2 (uMR 880), and 5.0 T MRI (uMR Jupiter).

Results: The high spatial resolution of 5.0 T MRI improves the quantification accuracy of PDFF and R2* in abdominal multi-organs.

Impact: Due to high interfield agreement of the PDFF and R2* with 3.0 T, 5.0 T could be used as a reliable noninvasive biomarker for quantifying fat and iron contents.

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Keywords