Abstract #5013

Inter-Rater Reliability of RANO2 Criteria in Assessing Tumor Response in Low-Grade Gliomas Treated With and Without Radiation

Parisa Arjmand^1,2, Grayson Warren Hooper^1,2, Wassim Malak^1,2, Yilun Sun², Robin Ghotra¹, Sree Gongala^1,2, Herbert Newton^2,3,4, Prashant Vempati^2,3,4, Haley Perlow^2,3, Tiffany Hodges^2,4,5, and Chaitra Badve^1,2,4

¹Department Of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ²Case Western Reserve University School of Medicine, Cleveland, OH, United States, ³Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁴Seidman Cancer Center and Case Comprehensive Cancer Center, Cleveland, OH, United States, ⁵Neurological Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

Synopsis

Keywords: Tumors (Post-Treatment), Tumors

Motivation: The value of updated RANO2 criteria for assessing tumor response in low-grade gliomas (LGG), especially in post-radiation therapy (RT) setting is unknown.

Goal(s): To evaluate the accuracy and inter-rater reliability (IRR) of the RANO2 criteria in LGG patients with and without RT.

Approach: Retrospective analysis of 26 LGGs by three readers to measure IRR and accuracy compared to ground truth.

Results: RANO2 demonstrates excellent IRR in without-RT (Intraclass correlation coefficient, ICC = 0.986) but moderate in post-RT (ICC = 0.516) LGGs. Accuracy is higher with the use of baseline scans compared to immediate priors in post RT cases (AUC 0.9 vs 0.6, respectively).

Impact: This research highlights the challenges of implementing RANO2 criteria in post-treatment LGG monitoring. The lower IRR in the post-radiation setting and lower accuracy in the absence of baseline scans emphasize the need for an alternative imaging approach beyond RANO2.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.