Abstract #5042

Myelin Assessment in Neurodegeneration: Correlation of R1 Relaxation and Diamagnetic Susceptibility in White Matter Using χ-Separation

Masaaki Hori¹, Kouhei Kamiya¹, Junya Ebina², Masahiro Kobayashi¹, Sunao Mizumura¹, Hitoshi Terada³, Katsutoshi Murata⁴, Jongho Lee⁵, and Osamu Kano²

¹Radiology, Toho University, Tokyo, Japan, ²Neurology, Toho University, Tokyo, Japan, ³Department of Radiology, Toho University Sakura Medical Center, Chiba, Japan, ⁴Siemens Healthcare K.K., Tokyo, Japan, ⁵Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Synopsis

Keywords: Other Neurodegeneration, White Matter, R1, myelin, susceptibility source, χ-separation

Motivation: Accurately assessing myelin content in white matter is vital for tracking neurodegenerative disease progression. Standard MRI metrics like R1 are affected by factors like iron, highlighting the need for a specific myelin marker

Goal(s): This study explores the correlation between R1 and diamagnetic susceptibility (χ_dia) in white matter, evaluating χ_dia’s suitability as a myelin-specific marker.

Approach: Twenty-seven patients with Parkinsonian syndromes underwent MP2RAGE and QSM imaging at 3T. χ_dia maps and R1 maps were compared across 48 white matter regions.

Results: Low overall correlation between R1 and χ_dia suggests R1 reflects additional influences, while χ_dia may better indicate myelin in specific regions.

Impact: A novel methodχ-separation enables myelin assessment in neurodegenerative white matter, reducing iron's confounding effects. This method allows researchers to study myelin independently, potentially enhancing diagnostic precision in neurodegenerative disease Synopsis

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