Abstract #5047

Simultaneous Dynamic Sodium (23Na) MRI and EEG Analysis of Cerebrospinal Fluid Flow Velocity in the Human Brain During Sleep

Ying-Chia Lin^1,2, Kennedy Watson¹, Xingye Chen^1,3, Simon Henin⁴, Nahbila-Malikha Kumbella⁵, Justin Quimbo⁵, Yulin Ge¹, Arjun Masurkar⁶, Anli Liu⁴, Yvonne W. Lui¹, and Yongxian Qian¹

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York Universi, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁴Comprehensive Epilepsy Center, Department of Neurology, New York University Grossman School of Medicine, New York, New York, NY, United States, ⁵Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁶Alzheimer’s Disease Research Center, Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Neurofluids, Aging, Sodium MRI, EEG, Sleep

Motivation: Alzheimer's disease involves neurotoxic amyloid-beta (Aβ) plaques. In mice, impaired CSF clearance reduces Aβ removal by 70%. Sleep may boost CSF clearance by expanding extracellular space, potentially affecting CSF flow velocity.

Goal(s): The impact of sleep on CSF flow in humans remains unclear due to limited non-invasive imaging.

Approach: Using sodium (23Na) MRI, we measured extracellular volume in 29 healthy brains, with sleep stages monitored via MRI-compatible EEG.

Results: We observed significant differences in CSF flow velocity between gray matter (GM) and white matter (WM) during sleep stages W, N2, and N3, though no clear velocity trends across stages were found.

Impact: This work may clarify sleep’s role in Aβ clearance in humans.

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