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Abstract #5051

Longitudinal Assessment of Whole-brain Perfusion in Mice with Transient Middle Cerebral Artery Occlusion by BOLD-DSC MRI

Thuy Thi Le1,2,3, Geun Ho Im1, and Seong-Gi Kim1,2,3
1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Stroke, Stroke, DSC, transient MCAO

Motivation: To further validate the use of non-invasive BOLD-DSC for longitudinal assessment of hemodynamics in ischemic stroke progression.

Goal(s): To assess CBV and CBF dynamics across pre-occlusion, occlusion, and reperfusion phases, extending up to four hours post-30-minute filament-induced transient middle cerebral artery occlusion (tMCAO) in mice.

Approach: Whole-brain CBV and CBF were measured non-invasively using BOLD-DSC with 5-second hypoxic challenges (0% O2) at 9.4T

Results: Significant reductions in CBV and CBF were observed during MCA occlusion, with partial restoration evident during the reperfusion phase.

Impact: This study demonstrates the utility of BOLD-DSC MRI as a non-invasive, real-time approach to monitor hemodynamic changes in ischemic stroke, revealing both the immediate and prolonged effects of transient ischemia on CBV and CBF.

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