Abstract #5063

MRI Evaluation of Cerebral Microbleeds, Silent Infarct, Iron Deposit with QSM in Sickle Cell Disease and Thalassemia Compared to Healthy Controls

Hon J Yu¹, Wilson Lin², Min-Ying Su¹, Hung P Do³, Dawn Berkeley³, Jennifer Soun¹, Yang Zhang⁴, Peter Chang¹, Jeon-Hor Chen¹, Brain Tymkiw³, Wissam AlGhuraibawi³, Mo Kadbi³, Mark Fisher⁵, and Zahra Pakbaz²

¹Department of Radiological Sciences, University of California, Irvine, CA, United States, ²Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, United States, ³Canon Medical Systems USA, Inc., Tustin, CA, United States, ⁴Department of Radiation Oncology, University of California, Irvine, CA, United States, ⁵Department of Neurology, University of California, Irvine, CA, United States

Synopsis

Keywords: Stroke, Blood

Motivation: Sickle cell disease (SCD) and Thalassemia are inherited blood disorders, and patients are likely to have small vessel disease, silent infarct, and cerebral microbleeds.

Goal(s): Multi-parametric MRI was used to evaluate clinically significant findings, and QSM was used to measure iron deposits in various brain regions.

Approach: A prospective study was performed by enrolling 30 subjects. The ROIs in the basal ganglia regions were segmented and mapped to QSM to measure susceptivity.

Results: Two sickle cell patients had cerebral microbleeds, and two had silent infarcts. The QSM susceptibility was distributed in a wide range, especially in patient groups.

Impact: Sickle cell and Thalassemia patients may need blood transfusions, which leads to iron overload. Brain iron may also increase due to microvasculature damage. QSM may be performed to evaluate iron deposit levels and microbleeds to help improve their precision care.

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