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Abstract #5074

Temporoparietal structural-functional coupling abnormalities in drug-naïve first-episode major depressive disorder

Qian Zhang1, Aoxiang Zhang1, Graham J Kemp2, Youjin Zhao1, and Qiyong Gong1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom., Liverpool, United Kingdom

Synopsis

Keywords: Psychiatric Disorders, Multimodal, major depressive disorder, diffusion tensor imaging, structural and functional connectivity couplingresting-state functional magnetic resonance imaging, brain connectivity, graph theory

Motivation: The relationship of connectivity patterns and topology of both structural and functional networks in MDD remain less well-understood.

Goal(s): We aimed to measure the coupling between structural connectivity (SC) and functional connectivity (FC) to explore the interplay between structural architecture and functional communications in MDD.

Approach: SC-FC couplings at system and regional levels and their relationship with topological properties and anxious depression subtype were assessed in MDD patients compared to controls.

Results: MDD showed altered SC-FC coupling and topology in temporoparietal regions than controls. Specifically, right hippocampal coupling differed between anxious and non-anxious MDD patients, showing distinct correlation patterns with structural network efficiency.

Impact: Our findings revealed disrupted topology-related interplay between structural and functional connectivity in temporoparietal regions in MDD, advancing understanding of MDD-related multimodal network abnormalities and highlighting the role of right hippocampal coupling alterations in identifying the anxious depression subtype.

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