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Abstract #5076

Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes

Baohong Wen1, Qiuying Tao1, Ya Tian1, Wenqing Shi1, Zijun Liu1, Jin Sun1, Yong Zhang1, Jingliang Cheng1, and Shaoqiang Han1
1the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: Gray Matter, Neurotransmission, Obsessive-compulsive disorder; Neuroanatomical; Heterogeneity; Subtype

Motivation: Obsessive-compulsive disorder (OCD) is a highly heterogeneous disorder, with notable variations among cases in structural brain abnormalities.

Goal(s): we aimed to identify distinct OCD subtypes based on individualized gray matter morphological abnormalities compared to normative expectations

Approach: We recruited 100 untreated, first-episode OCD patients and 106 healthy controls for structural imaging scans and identified subtype.

Results: Our findings revealed two distinct OCD subtypes exhibiting divergent patterns of structural brain abnormalities. Structural brain abnormalities in these subtypes displayed distinct associations with neurotransmitter receptors/transporters. The identified subtypes offer novel insights into nosology and the heterogeneous nature of OCD.

Impact: Two subtypes manifest opposite gray matter morphological abnormalities. Subtype exhibit divergent structural covariance network-informed disease epicenters. Gray matter morphological abnormalities of subtypes exhibit distinct associations with neurotransmitter receptors/transporters. Novel insights are offered into nosology and heterogeneous nature of OCD.

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